Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 18128생성일: 2026년 10월 24일
4-Chlorobutyryl chloride → 4-chloro-N-{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}butanamide
https://huagongshe.com/ko/reaction/18128
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Chlorobutyryl chloride | HCID 78370 | — |
| 반응물 | 11-amino-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione | HCID 10065413 | — |
| 반응물 | Dichloromethane methanol | HCID 21226129 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 4-chloro-N-{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-11-yl}butanamide | HCID 16717839 | 53% |
반응 단계
A solution of 100 mg (0.30 mmole) of 11-amino-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione (obtained in example 3) in 4 mL of acetonitrile was stirred at 20° C. 68 μL of 4-chlorobutyryl chloride were added. The mixture was magnetically stirred at 20° C. during 3 hours. The solvent was then evaporated under reduced pressure and the residue was submitted to a flash chromatography on silica (eluent: CH2Cl2/methanol in a 97:3 volume ratio) to provide 70 mg (yield: 53%) of the desired product (formula below) as an orange powder
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07741337B2 |
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| 출처 데이터셋 | uspto-grants-2010_06 |
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| ORD ID | ord-d398ed68e3d64337be7c927a2afc5f77 |
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| 출처 메모 | uspto-grants-2010_06 |
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