Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → HCID 178418429, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Ammonium Hydroxide | HCID 14923 | — |
| 반응물 | 3-cyano-4-trifluoromethylsulfenyl-5-(N-trifluoroacetylamino)pyrazole | HCID 178418360 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | HCID 178418429 | HCID 178418429 | 87.6% |
반응 단계
The product of Step E (55 g, 181 mmoles) was dissolved in methanol. 100 ml of ammonium hydroxide were added, the solution was refluxed for 3 hours and then stirred at room temperature for 15 hours. The methanolic solution was brought to pH7 using concentrated aqueous hydrochloric acid and diluted with ethyl acetate. The organic layer was washed several times with water and brine, dried over MgSO4 and concentrated to dryness to give an oily brown residue which was recrystallized from methyl tert-butyl ether to afford 33 g of the title compound, m.p. around 187° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05726324 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-519d1ed0c254438c8f86070fac54bfc1 |
| 출처 메모 | uspto-grants-1998_03 |