HCID 22505093, 화합물 → HCID 22505002, 화합물

HRID 1814037노트

반응식

HRID 1814037 반응식
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[C:4]([F:11])[C:3]=1[N:12]1[CH2:17][CH:16]2[CH:14]([O:15]2)[CH2:13]1.[H][H]>[Pd].C(OCC)(=O)C>[F:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[C:4]([F:11])[C:3]=1[N:12]1[CH2:17][CH:16]2[CH:14]([O:15]2)[CH2:13]1

참가 물질

5

반응물 2

HCID 22505093HCID 22505093, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 22505002HCID 22505002, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

10% Palladium on carbon (0.02 g) was added to 3-(2,6-difluoro-4-nitro-phenyl)-6-oxa-3-aza-bicyclo[3.1.0]hexane (0.2 g, 0.83 mmol) dissolved in ethyl acetate (8.0 mL). The flask was charged with hydrogen gas and the mixture was stirred at room temperature for 3 h. The reaction mixture was filtered through celite and the solvent removed to get the title compound which was used directly in the next reaction.

후처리

  1. filtrationThe reaction mixture was filtered through celite
  2. customthe solvent removed

출처 및 근거

ORD 기록
ord-a86c43f291124a21a6ab0c32345eab09
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06875784B2

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