Methanol → 2-(oxazol-2-yl)-5-methanesulfonyl-1H-pyrrolo[2,3-b]pyridine

HRID 1814054노트

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HRID 1814054 반응식
C1(S([N:10]2[C:14]3=[N:15][CH:16]=[C:17]([S:19]([CH3:22])(=[O:21])=[O:20])[CH:18]=[C:13]3[CH:12]=[C:11]2[C:23]2[O:24][CH:25]=[CH:26][N:27]=2)(=O)=O)C=CC=CC=1.[OH-].[K+].CO>O>[O:24]1[CH:25]=[CH:26][N:27]=[C:23]1[C:11]1[NH:10][C:14]2=[N:15][CH:16]=[C:17]([S:19]([CH3:22])(=[O:20])=[O:21])[CH:18]=[C:13]2[CH:12]=1

참가 물질

5

반응물 3

HCID 887MethanolHCID 14797Potassium HydroxideHCID 225043901-benzenesulfonyl-2-(oxazol-2-yl)-5-methanesulfonyl-1H-pyrrolo[2,3-b]pyridine

생성물 1

HCID 225043982-(oxazol-2-yl)-5-methanesulfonyl-1H-pyrrolo[2,3-b]pyridine수율 83.2%

시약·촉매·용매 1

HCID 962Water용매

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온도
22.5 °C

실험 절차

A mixture of 1-benzenesulfonyl-2-(oxazol-2-yl)-5-methanesulfonyl-1H-pyrrolo[2,3-b]pyridine (0.35 g), potassium hydroxide (0.34 g) and methanol (30 ml) was stirred at 15 to 30° C. for 30 minutes. To the reaction mixture was added water, the resulting mixture was extracted with dichloromethane, washed with a saturated aqueous NaCl solution, dried over sodium sulfate and concentrated under reduced pressure. The resulting residue was subjected to silica gel column chromatography (hexane:ethyl acetate=1:1) to obtain 0.19 g of the desired product.

후처리

  1. extractionthe resulting mixture was extracted with dichloromethane
  2. washwashed with a saturated aqueous NaCl solution
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-091edb99bc1c48418329a9c9f742c3e8
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06875770B2

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