Water → HCID 22504420, 화합물

반응식

[O:1]1[CH2:6][CH2:5][C:4]([C:7]2[N:8]([S:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)(=[O:20])=[O:19])[C:9]3[C:14]([CH:15]=2)=[CH:13][C:12]([S:16][CH3:17])=[CH:11][CH:10]=3)=[CH:3][CH2:2]1.OOS([O-])=O.[K+].[OH2:33].O1CCCC1.[OH2:39]>>[O:1]1[CH2:6][CH2:5][C:4]([C:7]2[N:8]([S:18]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)(=[O:20])=[O:19])[C:9]3[C:14]([CH:15]=2)=[CH:13][C:12]([S:16]([CH3:17])(=[O:39])=[O:33])=[CH:11][CH:10]=3)=[CH:3][CH2:2]1

참가 물질

반응물 4

HCID 962Water

HCID 21881883Oxolane--water (1/1)

HCID 225044022-(5,6-dihydro-2H-4-pyranyl)-1-benzenesulfonyl-5-methylthioindole

HCID 23707502Potassium hydroxy sulfite

생성물 1

HCID 22504420HCID 22504420, 화합물

실험 절차

To a solution of the compound obtained in Example 14 (2) (33.7 mg) in a mixture of tetrahydrofuran/water (3:1, 4 ml), OXONE (registered trademark) (134 mg) was added at 15 to 30° C. and the mixture was stirred for 15 hours. The reaction solution was then poured into water, extracted with dichloromethane, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The resulting residue was separated using silica gel preparative thin-layer chromatography (hexane:ethyl acetate=1:1) to obtain 28.8 mg of the desired product as a white powder.