Methanol → methyl 2H-thiopyran-3-carboxylate

HRID 1814148노트

반응식

HRID 1814148 반응식
[S:1]1[CH2:6][CH2:5][CH:4]=[C:3]([C:7]([O-:9])=[O:8])[CH2:2]1.[CH3:10]O>[Pd].C>[S:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]([O:9][CH3:10])=[O:8])[CH2:2]1

참가 물질

4

반응물 2

HCID 887MethanolHCID 219460775,6-dihydro-2H-thiopyran-3-carboxylate

생성물 1

HCID 21946080methyl 2H-thiopyran-3-carboxylate수율 96%

시약·촉매·용매 1

HCID 14818447Palladiumcarbon촉매

실험 절차

A solution of 832 mg (4.37 mmole) of 5,6-dihydro-2H-thiopyran-3-carboxylate, 1,1 dioxide from part D in methanol (40 mL) was hydrogenated in the presence of 400 mg (50% wt) of 10% Pd/charcoal for 4 hrs. at room temperature and 50 psig of H2. The catalyst was removed by vacuum filtration through a short plug of packed celite and the solvent removed in vacuo to give 802 mg (96%) of methyl 2H-thiopyran-3-carboxylate, 1,1-dioxide as a white solid; mass spectrum m/z=193 (CI,M+H) Part F: Preparation of 2H-thiopyran-3-carboxylate, 1,1-dioxide.

후처리

  1. customat room temperature
  2. customThe catalyst was removed by vacuum filtration through a short plug of packed celite
  3. customthe solvent removed in vacuo

출처 및 근거

ORD 기록
ord-39b6a274d82046b1965447ee41c06458
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06875790B2

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