Methylamine → 2-Methylthiophene-3-carboxylic acid

2-Methyl-3-thiophenecarboxylate chloride (60.5 g)/THF (300 ml) solution was added dropwise to a 40% aqueous solution of methylamine (400 ml) at 0° C. Ethyl acetate (2 l) was added thereto, and then the organic layer was washed sequentially with water, a 5N aqueous solution of hydrochloride acid, an aqueous solution of saturated of saturated sodium bicarbonate, water and brine, dried and evaporated. The resulting residue was crystallized from n-hexane, to give the title compound as a white powder (43.5 g, yield; 71.8%).

1. washthe organic layer was washed sequentially with water
2. dry with materiala 5N aqueous solution of hydrochloride acid, an aqueous solution of saturated of saturated sodium bicarbonate, water and brine, dried
3. customevaporated
4. customThe resulting residue was crystallized from n-hexane

ORD 기록

ord-543d502e31254f8e811ab60f5ce57690

출처 데이터셋

uspto-grants-2005_04

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US06875761B2