Pyridine → 3-{3-(4-tert-butylphenyl)-3-[4-(2H-tetrazol-5-ylcarbamoyl)benzyl]ureido}benzoic acid pentafluorophenyl ester

HRID 1814695노트

반응식

HRID 1814695 반응식
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([N:11]([CH2:24][C:25]2[CH:30]=[CH:29][C:28]([C:31](=[O:38])[NH:32][C:33]3[N:34]=[N:35][NH:36][N:37]=3)=[CH:27][CH:26]=2)[C:12](=[O:23])[NH:13][C:14]2[CH:15]=[C:16]([CH:20]=[CH:21][CH:22]=2)[C:17]([OH:19])=[O:18])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].N1C=CC=CC=1.FC(F)(F)C(O[C:50]1[C:55]([F:56])=[C:54]([F:57])[C:53]([F:58])=[C:52]([F:59])[C:51]=1[F:60])=O>CN(C=O)C>[F:56][C:55]1[C:50]([O:18][C:17](=[O:19])[C:16]2[CH:20]=[CH:21][CH:22]=[C:14]([NH:13][C:12]([N:11]([C:8]3[CH:7]=[CH:6][C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])=[CH:10][CH:9]=3)[CH2:24][C:25]3[CH:30]=[CH:29][C:28]([C:31](=[O:38])[NH:32][C:33]4[N:34]=[N:35][NH:36][N:37]=4)=[CH:27][CH:26]=3)=[O:23])[CH:15]=2)=[C:51]([F:60])[C:52]([F:59])=[C:53]([F:58])[C:54]=1[F:57]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 4327891Pentafluorophenyl TrifluoroacetateHCID 225019653-{3-(4-tert-Butylphenyl)-3-[4-(2H-tetrazol-5-ylcarbamoyl)benzyl]ureido}benzoic acid

생성물 1

HCID 183469463-{3-(4-tert-butylphenyl)-3-[4-(2H-tetrazol-5-ylcarbamoyl)benzyl]ureido}benzoic acid pentafluorophenyl ester

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
25 °C

실험 절차

To the above resin bound 3-{3-(4-tert-butylphenyl)-3-[4-(2H-tetrazol-5-ylcarbamoyl)benzyl]ureido}benzoic acid was added a solution of pyridine (500 μL) in DMF (5 mL) followed by pentafluorophenyl trifluoroacetate (850 μL). The mixture was shaken for 4 hours at 25° C., filtered and washed with DMF (2×10 mL), affording the resin bound title compound.

후처리

  1. filtrationfiltered
  2. washwashed with DMF (2×10 mL)
  3. customaffording the resin

출처 및 근거

ORD 기록
ord-037a32ba1b414c8898caadacac476373
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06875760B2

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