tert-butyl 5-nitro-2,3-dihydro-1H-inden-2-ylcarbamate → tert-butyl N-(5-amino-2,3-dihydro-1H-inden-2-yl)carbamate

HRID 1814774노트

반응식

HRID 1814774 반응식
[C:1]([O:5][C:6](=[O:20])[NH:7][CH:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([N+:17]([O-])=O)[CH:14]=2)[CH2:9]1)([CH3:4])([CH3:3])[CH3:2]>C(O)C.[Pd]>[C:1]([O:5][C:6](=[O:20])[NH:7][CH:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([NH2:17])[CH:14]=2)[CH2:9]1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 1

HCID 54019012tert-butyl 5-nitro-2,3-dihydro-1H-inden-2-ylcarbamate

생성물 1

HCID 42609144tert-butyl N-(5-amino-2,3-dihydro-1H-inden-2-yl)carbamate

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A solution of (5-nitro-indan-2-yl)-carbamic acid tert-butyl ester (3.52 g, 12.6 mmol) in ethanol (100 mL) is degassed and 10% palladium on carbon added. The reaction is evacuated and placed under 1 atm H2(g) for 2 h. Filtration of the reaction mixture through Celite is followed by concentration of the filtrate under reduced pressure to give (5-amino-indan-2-yl)-carbamic acid tert-butyl ester as an oil which is used directly without further purification.

후처리

  1. customThe reaction is evacuated
  2. filtrationFiltration of the reaction mixture through Celite

출처 및 근거

ORD 기록
ord-eb4ee049d4f947beade1c3d186cbee08
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06878707B2

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