5-Benzyloxy-2-ethoxybenzonitrile → 2-Ethoxy-5-hydroxybenzonitrile

HRID 1814826노트

반응식

HRID 1814826 반응식
C([O:8][C:9]1[CH:10]=[CH:11][C:12]([O:17][CH2:18][CH3:19])=[C:13]([CH:16]=1)[C:14]#[N:15])C1C=CC=CC=1>CO.[Pd]>[CH2:18]([O:17][C:12]1[CH:11]=[CH:10][C:9]([OH:8])=[CH:16][C:13]=1[C:14]#[N:15])[CH3:19]

참가 물질

4

반응물 1

HCID 219731695-Benzyloxy-2-ethoxybenzonitrile

생성물 1

HCID 219731772-Ethoxy-5-hydroxybenzonitrile

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

40.02 g of 5-benzyloxy-2-ethoxybenzonitrile (158 mmol) (example 32A) and 5% Pd/C (4.0 g) are initially charged in 1 l of methanol. The mixture is then hydrogenated under an atmosphere of hydrogen (1 atm) for about 4 h. The mixture is filtered through kieselguhr and evaporated and the crystalline residue is dried under reduced pressure.

후처리

  1. filtrationThe mixture is filtered through kieselguhr
  2. customevaporated
  3. customthe crystalline residue is dried under reduced pressure

출처 및 근거

ORD 기록
ord-9fb0b2482bc2416c95f7ad4b8a4d785b
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06878708B2

반응 노트

불러오는 중…