HCID 69744124, 화합물 → HCID 135718994, 화합물

HRID 1815215노트

반응식

HRID 1815215 반응식
C[O:2][C:3](=[O:47])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10](N(C(C2N(OCC3C=CC=CC=3)C(C3CCCCC3)NC=2COC23CC4CC(CC(C4)C2)C3)=O)N)=O)[CH:5]=1.[C:48]12([O:58][CH2:59][C:60]3[NH:64][CH:63]([CH:65]4[CH2:70][CH2:69][CH2:68][CH2:67][CH2:66]4)[N:62]([O:71]CC4C=CC=CC=4)[C:61]=3[C:79]([NH:81][NH2:82])=[O:80])[CH2:57][CH:52]3[CH2:53][CH:54]([CH2:56][CH:50]([CH2:51]3)[CH2:49]1)[CH2:55]2.C12(OCC3NC(C4CCCCC4)=NC=3C(NN)=O)CC3CC(CC(C3)C1)C2>>[C:48]12([O:58][CH2:59][C:60]3[NH:64][CH:63]([CH:65]4[CH2:66][CH2:67][CH2:68][CH2:69][CH2:70]4)[N:62]([OH:71])[C:61]=3[C:79]3[O:80][C:10]([C:6]4[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=4)[C:3]([OH:47])=[O:2])=[N:82][N:81]=3)[CH2:55][CH:54]3[CH2:56][CH:50]([CH2:51][CH:52]([CH2:53]3)[CH2:57]1)[CH2:49]2

참가 물질

4

반응물 3

HCID 69744124HCID 69744124, 화합물HCID 69744154HCID 69744154, 화합물HCID 69744697HCID 69744697, 화합물

생성물 1

HCID 135718994HCID 135718994, 화합물

실험 절차

3-{N1-[5-(Adamantan-1-yloxymethyl)-3-benzyloxy-2-cyclohexyl-1H-imidazole-4-carbonyl]-hydrazinocarbonyl}-benzoic acid methyl ester. The title compound was prepared essentially using the procedure in Example 8, step b, with the modification that 5-(Adamantan-1-yloxymethyl)-3-benzyloxy-2-cyclohexyl-1H-imidazole-4-carboxylic acid hydrazide. was used instead of 5-(Adamantan-1-yloxymethyl)-2-cyclohexyl-1H-imidazole-4-carboxylic acid hydrazide. 1H NMR (CDCl3) 11.16 (1H, d), 9.21 (1H, br s), 8.51 (1H, s), 8.20 (1H, d), 8.12 (1H, d), 7.54 (1H, t), 7.46 (2H, m), 7.38 (3H, m), 5.33 (2H, s), 4.74 (2H, s), 3.94 (3H, s), 2.60 (1H, m), 2.17 (3H, br s), 1.90 (6H, s), 1.79 (2H, m), 1.62 (11H, m), 1.26 (3H, m).

출처 및 근거

ORD 기록
ord-cff259f98feb4eabb0ba527b3d7ed80c
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06878734B2

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