HCID 69744124, 화합물 → HCID 135718994, 화합물

HRID 1815216노트

반응식

HRID 1815216 반응식
C[O:2][C:3](=[O:46])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[O:11][C:12]([C:15]3[N:16]([O:38]CC4C=CC=CC=4)[CH:17]([CH:32]4[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]4)[NH:18][C:19]=3[CH2:20][O:21][C:22]34[CH2:31][CH:26]5[CH2:27][CH:28]([CH2:30][CH:24]([CH2:25]5)[CH2:23]3)[CH2:29]4)=[N:13][N:14]=2)[CH:5]=1.COC(=O)C1C=CC=C(C(N(C(C2N(OCC3C=CC=CC=3)C(C3CCCCC3)NC=2COC23CC4CC(CC(C4)C2)C3)=O)N)=O)C=1>>[C:22]12([O:21][CH2:20][C:19]3[NH:18][CH:17]([CH:32]4[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]4)[N:16]([OH:38])[C:15]=3[C:12]3[O:11][C:10]([C:6]4[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=4)[C:3]([OH:46])=[O:2])=[N:14][N:13]=3)[CH2:23][CH:24]3[CH2:30][CH:28]([CH2:27][CH:26]([CH2:25]3)[CH2:31]1)[CH2:29]2

참가 물질

3

반응물 2

HCID 69744124HCID 69744124, 화합물HCID 136377659HCID 136377659, 화합물

생성물 1

HCID 135718994HCID 135718994, 화합물

실험 절차

3-{5-[5-(Adamantan-1-yloxymethyl)-3-benzyloxy-2-cyclohexyl-1H-imidazol-4-yl]-[1,3,4]oxadiazol-2-yl}-benzoic acid methyl ester. The title compound was prepared essentially using the procedure in Example 9, step a, with the modification that 3-{N1-[5-(Adamantan-1-yloxymethyl)-3-benzyloxy-2-cyclohexyl-1H-imidazole-4-carbonyl]-hydrazinocarbonyl}-benzoic acid methyl ester was used instead of 3-{N1-[5-(Adamantan-1-yloxymethyl)-2-cyclohexyl-1H-imidazole-4-carbonyl]-hydrazinocarbonyl}-benzoic acid methyl ester. 1H NMR (CDCl3) 8.77 (1H, s), 8.33 (1H, d), 8.24 (1H, d), 7.63 (1H, t), 7.53 (2H, m), 7.45 (3H, m), 5.37 (2H, s), 4.77 (2H, s), 3.97 (3H, s), 2.73 (1H, m), 2.14 (3H, br s), 1.87-1.56 (19H, m), 1.27 (3H, m).

출처 및 근거

ORD 기록
ord-8391e8cd4e2c434f97085ddde6b91846
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06878734B2

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