Ethyl 4-methylpentanoate → HCID 69052716, 화합물

HRID 1815300노트

반응식

HRID 1815300 반응식
Cl.[NH2:2][CH2:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=O.[CH2:12]([CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH:13]([CH3:15])[CH3:14].C([O-])(=O)C.[Na+]>O>[CH2:20]([O:19][C:17]([C:16]1[C:4]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)=[CH:3][NH:2][C:12]=1[CH:13]([CH3:15])[CH3:14])=[O:18])[CH3:21]

참가 물질

5

반응물 3

HCID 117477Ethyl 4-methylpentanoateHCID 517045Sodium AcetateHCID 2723597Ethanone, 2-amino-1-phenyl-, hydrochloride (1:1)

생성물 1

HCID 69052716HCID 69052716, 화합물수율 93%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

A mixture of 2-aminoacetophenone hydrochloride (1 equiv.), ethyl isobutylacetate (1.2 equiv.) and sodium acetate (2.4 equiv.) in H2O was stirred at 100° C. for 18 hours and then cooled to room temperature. The aqueous layer was decanted off and the oil was dissolved in ethyl acetate. It was then washed with water and brine and then dried to give (93%) of 2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester as a red brown oil.

후처리

  1. temperaturecooled to room temperature
  2. customThe aqueous layer was decanted off
  3. dissolutionthe oil was dissolved in ethyl acetate
  4. washIt was then washed with water and brine
  5. customdried

출처 및 근거

ORD 기록
ord-83df263eee55429f9907a1f9cfc2c7b0
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06878733B1

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