2-Amino-3-phenylbutanoic acid → 5-chloro-N-[(1S)-1-cyclohexyl-2-hydroxyethyl]thiophene-2-sulfonamide

HRID 1815624

반응식

HRID 1815624 반응식
[Cl:1][C:2]1[S:6][C:5]([S:7](Cl)(=[O:9])=[O:8])=[CH:4][CH:3]=1.BrC1SC(S(Cl)(=O)=O)=CC=1.[CH2:21]1[CH2:26][CH2:25][CH:24]([C@H:27]([NH2:31])[C:28](O)=[O:29])[CH2:23][CH2:22]1.CC(C1C=CC=CC=1)C(C(O)=O)N.N[C@H](C(O)=O)[C@@H](CC)C>>[Cl:1][C:2]1[S:6][C:5]([S:7]([NH:31][C@@H:27]([CH:24]2[CH2:25][CH2:26][CH2:21][CH2:22][CH2:23]2)[CH2:28][OH:29])(=[O:9])=[O:8])=[CH:4][CH:3]=1

참가 물질

6

반응물 5

HCID 648082-Amino-3-phenylbutanoic acidHCID 99288Alloisoleucine, DL-HCID 736848(alphaS)-alpha-Aminocyclohexaneacetic acidHCID 27339245-Bromothiophene-2-sulfonyl chlorideHCID 27339255-Chlorothiophene-2-sulfonyl chloride

생성물 1

HCID 129874755-chloro-N-[(1S)-1-cyclohexyl-2-hydroxyethyl]thiophene-2-sulfonamide

실험 절차

The following compounds (Examples 12-17, Table 4) were prepared using 5-chlorothiophene-2-sulfonyl chloride, and 5-bromothiophene-2-sulfonyl chloride with L-cyclohexylglycine, β-methyl-DL-phenylalanine, and L-allo-isoleucine and following the procedure outlined in Example 12.

후처리

  1. customThe following compounds (Examples 12-17, Table 4) were prepared

출처 및 근거

ORD 기록
ord-92d5e0741acd47eb98f36cb9f281c1a3
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06878742B2

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