4-Toluenesulfonyl chloride → 4,7-Bis(p-tolylsulphonyl)-1,4,7-triazacyclononane

HRID 1815741

반응식

HRID 1815741 반응식
N1CCNCCNCC1.[C:10]1(C)[CH:15]=CC(S(Cl)(=O)=O)=C[CH:11]=1.[C:21]1([CH3:49])[CH:26]=[CH:25][C:24]([S:27]([N:30]2[CH2:38][CH2:37][NH:36][CH2:35][CH2:34][N:33]([S:39]([C:42]3[CH:47]=[CH:46][C:45]([CH3:48])=[CH:44][CH:43]=3)(=[O:41])=[O:40])[CH2:32][CH2:31]2)(=[O:29])=[O:28])=[CH:23][CH:22]=1.ICCCI.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[C:21]1([CH3:49])[CH:26]=[CH:25][C:24]([S:27]([N:30]2[CH2:38][CH2:37][NH:36][CH2:35][CH2:34][N:33]([S:39]([C:42]3[CH:47]=[CH:46][C:45]([CH3:48])=[CH:44][CH:43]=3)(=[O:40])=[O:41])[CH2:32][CH2:31]2)(=[O:29])=[O:28])=[CH:23][CH:22]=1.[CH3:11][CH2:10][CH3:15].[C:21]1([CH3:49])[CH:26]=[CH:25][C:24]([S:27]([N:30]2[CH2:38][CH2:37][NH:36][CH2:35][CH2:34][N:33]([S:39]([C:42]3[CH:47]=[CH:46][C:45]([CH3:48])=[CH:44][CH:43]=3)(=[O:40])=[O:41])[CH2:32][CH2:31]2)(=[O:29])=[O:28])=[CH:23][CH:22]=1

참가 물질

8

반응물 5

HCID 73974-Toluenesulfonyl chlorideHCID 11430Potassium CarbonateHCID 123141,3-DiiodopropaneHCID 1883181,4,7-TriazacyclononaneHCID 109062624,7-Bis(p-tolylsulphonyl)-1,4,7-triazacyclononane

생성물 2

HCID 109062624,7-Bis(p-tolylsulphonyl)-1,4,7-triazacyclononaneHCID 17939386HCID 17939386, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

N,N′-bis(p-Toluenesulfonyl)-1,4,7-triazacyclononane (1.1.20) was prepared by reacting (1.1.3) with two equivalents of p-toluenesulfonyl chloride. Two equivalents of N,N′-bis(p-toluenesulfonyl)-1,4,7-triazacyclononane (1.1.20) hydrobromide were reacted with one equivalent of 1,3-diiodopropane in acetonitrile with excess potassium carbonate. 1,3-bis[N,N′-bis(p-Toluenesulfonyl)-1,4,7-triazacyclononane propane (1.1.21) was isolated and purified by chromatography. The p-toluene-sulfonyl groups were removed using sulfuric acid and HBr to yield the title compound (1.1.19). 1.1.22 1,4,7,10-Tetraazabicyclo[5.5.2]tetradecane

출처 및 근거

ORD 기록
ord-40ea47cb16174880a641f1495dd0ae66
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06881732B2

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