1-Benzyl-3-methyl-4-piperidone → 1-Benzyl-3-methyl-4-hydroxy-4-(5-methoxybenzofur-7-yl)piperidine

반응식

[CH3:1][O:2][C:3]1[CH:4]=[C:5](Br)[C:6]2[O:10][CH:9]=[CH:8][C:7]=2[CH:11]=1.[CH2:13]([N:20]1[CH2:25][CH2:24][C:23](=[O:26])[CH:22]([CH3:27])[CH2:21]1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH2:13]([N:20]1[CH2:25][CH2:24][C:23]([OH:26])([C:5]2[C:6]3[O:10][CH:9]=[CH:8][C:7]=3[CH:11]=[C:3]([O:2][CH3:1])[CH:4]=2)[CH:22]([CH3:27])[CH2:21]1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

참가 물질

반응물 2

HCID 5609651-Benzyl-3-methyl-4-piperidone

HCID 221447037-Bromo-5-methoxy-1-benzofuran

생성물 1

HCID 224957491-Benzyl-3-methyl-4-hydroxy-4-(5-methoxybenzofur-7-yl)piperidine수율 54%

실험 절차

Beginning with 4.0 gm (17.6 mMol) 5-methoxy-7-bromobenzofuran and 3.94 gm (19.4 mMol) 1-benzyl-3-methyl-4-oxo-piperidine, 3.33 gm (54%) of the desired compound were recovered essentially as described in EXAMPLE 3.

출처 및 근거

ORD 기록: ord-ee58f2b543f049179e804c1d4a674cbb
출처 데이터셋: uspto-grants-2005_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06881733B1

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