HCID 22495688, 화합물 → HCID 69744908, 화합물

HRID 1815856노트

반응식

HRID 1815856 반응식
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11](O)([C:14]2[C:22]3[O:21][CH:20]=[CH:19][C:18]=3[CH:17]=[CH:16][C:15]=2[F:23])[CH:10]([CH2:25][CH3:26])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N1CCC(OC(=O)C(C)=O)(C2C3OC=CC=3C=CC=2F)C(CC)C1)C1C=CC=CC=1>>[CH2:1]([N:8]1[CH2:13][CH2:12][C@H:11]([C:14]2[C:22]3[O:21][CH:20]=[CH:19][C:18]=3[CH:17]=[CH:16][C:15]=2[F:23])[C@H:10]([CH2:25][CH3:26])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 22495688HCID 22495688, 화합물HCID 22495710HCID 22495710, 화합물

생성물 1

HCID 69744908HCID 69744908, 화합물수율 95.1%

실험 절차

Beginning with 5.4 gm (15.3 mMol) 1-benzyl-3-ethyl-4-hydroxy-4-(6-fluorobenzofur-7-yl)piperidine, 5.91 gm (88%) 1-benzyl-3-ethyl-4-(methyl oxoacetoxy)-4-(6-fluorobenzofur-7-yl)piperidine was recovered as an orange oil, essentially as described in EXAMPLE 16. This material was treated with tri(n-butyl)tin hydride essentially as described in EXAMPLE 16 to provide 4.91 gm of the desired compound.

후처리

  1. customwas recovered as an orange oil
  2. additionThis material was treated with tri(n-butyl)tin hydride essentially

출처 및 근거

ORD 기록
ord-9bf9289dffec4f1ea2a8aee263834dc3
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06881733B1

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