1-Benzyl-3-methyl-4-piperidone → HCID 22495572, 화합물

반응식

[F:1][C:2]1[CH:10]=[CH:9][C:5]2[CH:6]=[CH:7][O:8][C:4]=2[C:3]=1Br.[CH2:12]([N:19]1[CH2:24][CH2:23][C:22](=[O:25])[CH:21]([CH3:26])[CH2:20]1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH2:12]([N:19]1[CH2:24][CH2:23][C:22]([OH:25])([C:3]2[C:4]3[O:8][CH:7]=[CH:6][C:5]=3[CH:9]=[CH:10][C:2]=2[F:1])[CH:21]([CH3:26])[CH2:20]1)[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

참가 물질

반응물 2

HCID 5609651-Benzyl-3-methyl-4-piperidone

HCID 221449297-Bromo-6-fluoro-1-benzofuran

생성물 1

HCID 22495572HCID 22495572, 화합물수율 89.9%

실험 절차

Beginning with 12.7 gm (59 mMol) 6-fluoro-7-bromobenzofuran and 13.2 gm (65 mMol) 1-benzyl-3-methyl-4-oxopiperidine, 18 gm of the desired compound was prepared as an orange oil essentially as described in EXAMPLE 19.

출처 및 근거

ORD 기록: ord-52f8218739dc4e049dba7d562ba96309
출처 데이터셋: uspto-grants-2005_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06881733B1

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