6-Benzyloxy-1-[(S)-2-(tert-butyldimethyl-silanyloxy)-propyl]-1H-indazole → 1-[(S)-2-(tert-Butyldimethyl-silanyloxy)-propyl]-1H-indazol-6-ol

HRID 1815960

반응식

HRID 1815960 반응식
C([O:8][C:9]1[CH:17]=[C:16]2[C:12]([CH:13]=[N:14][N:15]2[CH2:18][C@@H:19]([O:21][Si:22]([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:24])[CH3:23])[CH3:20])=[CH:11][CH:10]=1)C1C=CC=CC=1>CO.[Pd]>[C:25]([Si:22]([CH3:24])([CH3:23])[O:21][C@@H:19]([CH3:20])[CH2:18][N:15]1[C:16]2[C:12](=[CH:11][CH:10]=[C:9]([OH:8])[CH:17]=2)[CH:13]=[N:14]1)([CH3:27])([CH3:28])[CH3:26]

참가 물질

4

반응물 1

HCID 695717436-Benzyloxy-1-[(S)-2-(tert-butyldimethyl-silanyloxy)-propyl]-1H-indazole

생성물 1

HCID 1364116801-[(S)-2-(tert-Butyldimethyl-silanyloxy)-propyl]-1H-indazol-6-ol수율 90.5%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of the product from Step A (5.44 g, 13.7 mmol) and palladium-on-carbon (10%, 0.50 g) in methanol (200 mL) was stirred under an atmosphere of hydrogen for 18 h, filtered and evaporated to give an off-white solid (3.80 g, 90%): mp 171-172° C.

후처리

  1. filtrationfiltered
  2. customevaporated

출처 및 근거

ORD 기록
ord-b83f797b975d4af7947fd744d5a61714
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06881749B2

연결된 노트

불러오는 중…