Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl vinyl ether → 7-Bromo-6-[3-bromo-2-(1-ethoxyethoxy)-propoxy]-1-[(S)-2-(tert-butyldimethyl-silanyloxy)-propyl]-1H-indazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl vinyl ether | HCID 8023 | — |
| 반응물 | 1-Bromo-3-[7-bromo-1-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-1H-indazol-6-yloxy]-propan-2-ol | HCID 69564280 | — |
| 촉매 | p-Toluenesulfonic acid | HCID 6101 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 7-Bromo-6-[3-bromo-2-(1-ethoxyethoxy)-propoxy]-1-[(S)-2-(tert-butyldimethyl-silanyloxy)-propyl]-1H-indazole | HCID 69565248 | 85.1% |
반응 단계
To a solution of the product from Step E (1.85 g, 3.54 mmol) and p-toluenesulfonic acid (0.01 g) in dichloromethane (50 mL) at 0° C. was added ethyl vinyl ether (1 mL, 10.5 mmol). After 30 min the reaction was quenched with a saturated solution of sodium bicarbonate (50 mL) and extracted with EtOAc (3×80 mL). Evaporation and purification by chromatography (silica, 1% to 8% EtOAc/hexane) gave a viscous oil (1.79 g, 81%): LC/MS (+APCI) m/z 595 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06881749B2 |
| 출처 데이터셋 | uspto-grants-2005_04 |
| ORD ID | ord-5db1d6e901934fd2839379fc377ad21a |
| 출처 메모 | uspto-grants-2005_04 |