홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Sodium triacetoxyborohydride → (S)-2-Chloro-5-[3-[(2-hydroxyproply)amino]propyl]-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide, hydrochloride salt

HRID 1816054
노트
인쇄 미리보기

반응식

HRID 1816054 반응식
C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].[Cl:15][C:16]1[CH:35]=[CH:34][C:33]([CH2:36][CH2:37][CH:38]=O)=[CH:32][C:17]=1[C:18]([NH:20][CH2:21][C:22]12[CH2:31][CH:26]3[CH2:27][CH:28]([CH2:30][CH:24]([CH2:25]3)[CH2:23]1)[CH2:29]2)=[O:19].[OH:40][C@@H:41]([CH3:44])[CH2:42][NH2:43]>ClCCl>[ClH:15].[Cl:15][C:16]1[CH:35]=[CH:34][C:33]([CH2:36][CH2:37][CH2:38][NH:43][CH2:42][C@@H:41]([OH:40])[CH3:44])=[CH:32][C:17]=1[C:18]([NH:20][CH2:21][C:22]12[CH2:31][CH:26]3[CH2:27][CH:28]([CH2:30][CH:24]([CH2:25]3)[CH2:23]1)[CH2:29]2)=[O:19]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 5049666Sodium triacetoxyborohydrideHCID 7311736(S)-(+)-1-Aminopropan-2-olHCID 120853482-Chloro-5(3-oxopropyl)-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide

생성물 1

HCID 10139105(S)-2-Chloro-5-[3-[(2-hydroxyproply)amino]propyl]-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide, hydrochloride salt수율 60.1%

시약·촉매·용매 1

HCID 6344
Dichloromethane
용매

실험 절차

Sodium triacetoxyborohydride (0.6 g) was added to a solution of 2-chloro-5-(3-oxopropyl)-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide (0.5 g, Example 14b) and (S)-2-hydroxypropylamine (0.31 g) in dichloromethane (5 ml). After 24 h the crude reaction mixture was purified by flash chromatography (eluting with 5-20% methanol in dichloromethane +1% ammonia) and the hydrochloride salt precipitated from ether/methanol 19: 1, to afford the title compound as a white solid (0.19 g).

후처리

  1. customAfter 24 h the crude reaction mixture
  2. customwas purified by flash chromatography (eluting with 5-20% methanol in dichloromethane +1% ammonia)
  3. customthe hydrochloride salt precipitated from ether/methanol 19: 1

출처 및 근거

ORD 기록
ord-5d8fa9e78c51445ba80d8cc5cc1e8544
출처 데이터셋
uspto-grants-2005_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06881754B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트