Potassium Carbonate → HCID 15510116, 화합물

HRID 1816201노트

반응식

HRID 1816201 반응식
[NH2:1][C:2]1[N:7]=[C:6](Cl)[N:5]=[C:4]([C:9]([F:12])([CH3:11])[CH3:10])[N:3]=1.C(=O)([O-])[O-].[K+].[K+].[C:19]1([CH2:25][CH2:26][CH2:27][CH:28]([NH2:32])[CH:29]2[CH2:31][CH2:30]2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C(#N)C>[NH2:1][C:2]1[N:3]=[C:4]([C:9]([F:12])([CH3:11])[CH3:10])[N:5]=[C:6]([NH:32][CH:28]([CH:29]2[CH2:31][CH2:30]2)[CH2:27][CH2:26][CH2:25][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[N:7]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 114468284-Chloro-6-(2-Fluoropropan-2-Yl)-1,3,5-Triazin-2-AmineHCID 17958117α-Cyclopropylbenzenebutanamine

생성물 1

HCID 15510116HCID 15510116, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매2회

실험 절차

1.52 g (0.008 mol) of 2-amino-4-chloro-6-(1-fluoro-1-methylethyl)-1,3,5-triazine and 1.64 g (0.012 mol) of potassium carbonate are introduced into 30 ml of acetonitrile. 1.50 g (0.008 mol) of 4-phenyl-1-cyclopropyl-1-butylamine, dissolved in 10 ml of acetonitrile, are added dropwise to this solution. The mixture is refluxed for three hours. The solid components are then filtered off with suction and the filtrate is evaporated on a rotary evaporator. The residue is purified by column chromatography (eluant: methyl acetate). This gives 2.36 g (86% of theory) of 2-amino-4-(1-fluoro-1-methylethyl)-6-(1-phenyl-4-cyclopropyl-4-butylamino)-1,3,5-triazine.

후처리

  1. additionare added dropwise to this solution
  2. temperatureThe mixture is refluxed for three hours
  3. filtrationThe solid components are then filtered off with suction
  4. customthe filtrate is evaporated on a rotary evaporator
  5. customThe residue is purified by column chromatography (eluant: methyl acetate)

출처 및 근거

ORD 기록
ord-a7e79d39029f466e8e98e27f53e1c200
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06884758B2

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