N'-(propan-2-ylidene)(tert-butoxy)carbohydrazide → N'-(propan-2-yl)(tert-butoxy)carbohydrazide

HRID 1816291노트

반응식

HRID 1816291 반응식
[CH3:1][C:2](=[N:4][NH:5][C:6]([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7])[CH3:3]>[Pd].C(O)(=O)C>[CH:2]([NH:4][NH:5][C:6]([O:8][C:9]([CH3:11])([CH3:10])[CH3:12])=[O:7])([CH3:3])[CH3:1]

참가 물질

4

반응물 1

HCID 11435207N'-(propan-2-ylidene)(tert-butoxy)carbohydrazide

생성물 1

HCID 11217534N'-(propan-2-yl)(tert-butoxy)carbohydrazide

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 176Acetic Acid용매

실험 절차

1-Methylethylidene-2-tert-butoxycarbonylhydrazine, glacial acetic acid (150 mL) and 10% palladium on carbon (2.0 g) were placed in a 500 mL Parr flask. The bottle was placed on a Parr apparatus, and after evacuating and flushing the bottle with nitrogen three times, the flask was charged with hydrogen to 40 psi. After hydrogen uptake ceased, the flask was evacuated and flushed with nitrogen. Filtration through celite, eluting with ethyl acetate, and concentration afforded the crude 1-(isopropyl)-2-tert-butoxycarbonylhydrazine as an acetic acid salt.

후처리

  1. customafter evacuating
  2. customflushing the bottle with nitrogen three times
  3. additionthe flask was charged with hydrogen to 40 psi
  4. customthe flask was evacuated
  5. customflushed with nitrogen
  6. filtrationFiltration through celite
  7. washeluting with ethyl acetate, and concentration

출처 및 근거

ORD 기록
ord-0849324a6ec6451f89c9d51f6e61325f
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06884801B1

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