2-Nitrobenzamide → N-[(dimethylamino)ethylidene]-2-nitrobenzamide

HRID 1816299노트

반응식

HRID 1816299 반응식
[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=1[C:6]([NH2:8])=[O:7])([O-:3])=[O:2].CO[C:15](OC)([N:17]([CH3:19])[CH3:18])[CH3:16]>>[CH3:18][N:17]([CH2:15][CH:16]=[N:8][C:6](=[O:7])[C:5]1[CH:9]=[CH:10][CH:11]=[CH:12][C:4]=1[N+:1]([O-:3])=[O:2])[CH3:19]

참가 물질

3

반응물 2

HCID 118762-NitrobenzamideHCID 878351,1-Dimethoxyethyl(dimethyl)amine

생성물 1

HCID 57019786N-[(dimethylamino)ethylidene]-2-nitrobenzamide

반응 조건

온도
120 °C

실험 절차

2-Nitrobenzamide (12.4 g, 75 mmol) was dissolved to dimethylacetamide-dimethylacetal (25 mL ) and heated to 120° C. for 2 hours. Upon cooling, the reaction was passed through a short silica column, eluting with ethyl acetate. The crystals that formed in the collected eluent were collected by filtration and rinsed with diethyl ether to provide N-[(dimethylamino)ethylidene]-2-nitrobenzamide (7.73 g).

후처리

  1. temperatureUpon cooling
  2. washeluting with ethyl acetate
  3. customThe crystals that formed in the collected eluent
  4. filtrationwere collected by filtration
  5. washrinsed with diethyl ether

출처 및 근거

ORD 기록
ord-aa53b9ca7e0b408fa77a16147ab5a853
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06884801B1

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