Sodium sulfide nonahydrate → 2-(3-Methyl-1,2,4-oxadiazol-5-yl)aniline

HRID 1816301노트

반응식

HRID 1816301 반응식
[CH3:1][C:2]1[N:6]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[N+:13]([O-])=O)[O:4][N:3]=1.O.O.O.O.O.O.O.O.O.[S-2].[Na+].[Na+]>O1CCOCC1.O>[CH3:1][C:2]1[N:6]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[NH2:13])[O:4][N:3]=1

참가 물질

5

반응물 2

HCID 73972Sodium sulfide nonahydrateHCID 126766793-Methyl-5-(2-nitrophenyl)-1,2,4-oxadiazole

생성물 1

HCID 126766822-(3-Methyl-1,2,4-oxadiazol-5-yl)aniline수율 62.1%

시약·촉매·용매 2

HCID 962Water용매HCID 312751,4-Dioxane용매

실험 절차

3-methyl-5-(2-nitrophenyl)-1,2,4-oxadiazole (1.0 g, 4.8 mmol) in dioxane (11 mL) at 80°0 C. was treated with 11 mL of an aqueous solution of sodium sulfide nonahydrate (2.55 g, 10.6 mmol), also at 80° C. After stirring at that temperature for 45 minutes, the reaction was diluted with water (15 mL) and cooled in an ice bath. The resulting precipitate was collected by filtration and rinsed with water to afford 3-methyl-5-(2-aminophenyl)-1,2,4-oxadiazole (522 mg).

후처리

  1. temperaturecooled in an ice bath
  2. filtrationThe resulting precipitate was collected by filtration
  3. washrinsed with water

출처 및 근거

ORD 기록
ord-5a38ef6cc2cd48e09ea0cb14ec319729
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06884801B1

반응 노트

불러오는 중…