4-Cyclohexylcyclohexanol → (1,1'-Bicyclohexyl)-4-one

HRID 1816335

반응식

HRID 1816335 반응식
[OH:1][CH:2]1[CH2:7][CH2:6][CH:5]([CH:8]2[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)[CH2:4][CH2:3]1>CC(C)=O>[CH:8]1([CH:5]2[CH2:4][CH2:3][C:2](=[O:1])[CH2:7][CH2:6]2)[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]1

참가 물질

3

반응물 1

HCID 755184-Cyclohexylcyclohexanol

생성물 1

HCID 41690(1,1'-Bicyclohexyl)-4-one수율 79.2%

시약·촉매·용매 1

HCID 180Acetone용매

반응 조건

온도
0 °C

실험 절차

To a solution of 4-hydroxycyclohexylcyclohexane (25 g) in acetone (250 ml) was added dropwise with stirring 2.67N Jone's regend (77 ml) at 0° C. The mixture was then stirred for 1 hour at 0° C. The organic layer was collected and evaporated. The reaction mixture was added to a mixture of water and diethyl ether. The organic layer was washed with water, sodium hydrogen carbonate solution and brine. The organic layer was taken and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was concentrated under reduced pressure to give 4-cyclohexylcyclohexanone (19.57 g).

후처리

  1. stirringThe mixture was then stirred for 1 hour at 0° C
  2. customThe organic layer was collected
  3. customevaporated
  4. additionThe reaction mixture was added to a mixture of water and diethyl ether
  5. washThe organic layer was washed with water, sodium hydrogen carbonate solution and brine
  6. dry with materialdried over magnesium sulfate
  7. filtrationThe magnesium sulfate was filtered off
  8. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-6538edd7f04946fca2640004d114912b
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06884774B2

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