Water → HCID 22493985, 화합물

HRID 1816570

반응식

HRID 1816570 반응식
[F:1][C:2]([F:22])([F:21])[C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:20])[CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[O:18][CH3:19])=[CH:5][CH:4]=1.C1N2CN3CN(C2)CN1C3.O.[C:34](=O)(O)[O-:35].[Na+]>FC(F)(F)C(O)=O.C(OCC)(=O)C>[F:1][C:2]([F:21])([F:22])[C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:20])[CH2:11][C:12]2[CH:17]=[C:16]([CH:34]=[O:35])[CH:15]=[CH:14][C:13]=2[O:18][CH3:19])=[CH:5][CH:4]=1

참가 물질

7

반응물 4

HCID 962WaterHCID 4101HexamethylenetetramineHCID 516892Sodium BicarbonateHCID 2684094N-[4-(trifluoromethyl)phenyl]-2-(2-methoxyphenyl)acetamide

생성물 1

HCID 22493985HCID 22493985, 화합물

시약·촉매·용매 2

HCID 6422Trifluoroacetic acid용매HCID 8857Ethyl Acetate용매

실험 절차

1.0 g of N-[4-(trifluoromethyl)phenyl]-2-(2-methoxyphenyl)acetamide was dissolved in 10 mg trifluoroacetic acid, and 0.46 g hexamethylene tetramine was added, and the mixture was reacted at 85° C. for 3 hours. The reaction solution was returned to room temperature, water and ethyl acetate were added, and sodium bicarbonate was further added until the pH reached 8. The reaction solution was extracted with ethyl acetate, washed with brine and dried over anhdydrous magnesium sulfate and the solvent was evaporated. The residue was subjected to silica gel column chromatography, to give 0.7 g of N-[4-(trifluoromethyl)phenyl]-2-(5-formyl-2-methoxyphenyl)acetamide as a colorless oil from fractions eluted with hexane-ethyl acetate (1:1).

후처리

  1. customthe mixture was reacted at 85° C. for 3 hours
  2. customwas returned to room temperature
  3. extractionThe reaction solution was extracted with ethyl acetate
  4. washwashed with brine
  5. dry with materialdried over anhdydrous magnesium sulfate
  6. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-fbf26c4fd6874849ba425fca38a1b74c
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06884821B1

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