m-Chloroperbenzoic acid → HCID 69801129, 화합물

HRID 1816591노트

반응식

HRID 1816591 반응식
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([O:10]O)=[O:9])[CH:3]=1.[CH:12]([O:15][CH:16]([CH2:22][C:23]1[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=1)[C:17]([O:19][CH2:20][CH3:21])=[O:18])([CH3:14])[CH3:13]>ClCCl.C(=O)([O-])O.[Na+]>[C:8]([O-:10])(=[O:9])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:2][CH2:3][CH2:4]/[CH:3]=[CH:2]\[CH2:7][CH2:6][CH2:27][CH2:28][CH2:23][CH2:22][CH2:16][CH3:17].[CH2:20]([O:19][C:17](=[O:18])[CH:16]([O:15][CH:12]([CH3:14])[CH3:13])[CH2:22][C:23]1[CH:24]=[CH:25][NH+:26]=[CH:27][CH:28]=1)[CH3:21]

참가 물질

5

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 22494133HCID 22494133, 화합물

생성물 1

HCID 69801129HCID 69801129, 화합물수율 119.8%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 516892Sodium Bicarbonate용매

실험 절차

6.0 g of m-chloroperbenzoic acid was added to a solution of 4.88 g ethyl 2-isopropoxy-3-(4-pyridyl)propanoate in dichloromethane (50 mL), followed by stirring at room temperature for 1.5 hours. After the reaction solution was diluted with saturated aqueous sodium hydrogencarbonate solution, the aqueous layer was extracted with dichloromethane for 3 times. The combined organic layer was dried over anhydrous sodium sulfate and then concentrated, to give 6.40 g crude 4-(3-ethoxy-2-isopropoxy-3-oxopropyl)-1-pyridinium oleate as a yellow oil.

후처리

  1. extractionthe aqueous layer was extracted with dichloromethane for 3 times
  2. dry with materialThe combined organic layer was dried over anhydrous sodium sulfate
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-32c0ad75e1a344c8abb11f739e7a6914
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06884821B1

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