Water → 3-(Azidomethyl)-2-methoxypyridine

HRID 1816606노트

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HRID 1816606 반응식
[CH3:1][O:2][C:3]1[C:8]([CH2:9]O)=[CH:7][CH:6]=[CH:5][N:4]=1.C1(P([N:25]=[N+:26]=[N-:27])(C2C=CC=CC=2)=O)C=CC=CC=1.C12CCCCC1CCCNN=2.O>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[C:8]([CH2:9][N:25]=[N+:26]=[N-:27])=[CH:7][CH:6]=[CH:5][N:4]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 199401P,P-Diphenylphosphinic azideHCID 10630565(2-Methoxypyridin-3-yl)methanolHCID 66879275Diazabicyclo[5.4.0]undecene

생성물 1

HCID 224939123-(Azidomethyl)-2-methoxypyridine

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

7.4 g of 2-methoxy-3-hydroxymethylpyridine was dissolved in 100 ml toluene, and 13.8 ml diphenyl phosphoryl azide and 9.5 ml diazabicyclo[5.4.0]undecene were added, and the mixture was stirred overnight at room temperature. Water was added to the reaction product which was then extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate and the solvent was evaporated, to give 9.5 g of [(2-methoxy-3-pyridyl)methyl]azide.

후처리

  1. extractionwas then extracted with ethyl acetate
  2. washThe organic layer was washed with brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-ce86c1b95beb4a3ebd84d1468b145ddc
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06884821B1

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