Acetic Acid → 1-Methoxy-1,1'-bicyclohexane-4-one

HRID 1816764노트

반응식

HRID 1816764 반응식
[CH:1]1([C:7]2([O:17][CH3:18])[CH2:16][CH2:15][C:10]3(OCC[O:11]3)[CH2:9][CH2:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(O)(=O)C.C(=O)([O-])O.[Na+].C(OCC)C>O>[CH3:18][O:17][C:7]1([CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2)[CH2:16][CH2:15][C:10](=[O:11])[CH2:9][CH2:8]1

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 3283Diethyl EtherHCID 516892Sodium BicarbonateHCID 224947668-Cyclohexyl-8-methoxy-1,4-dioxaspiro[4.5]decane

생성물 1

HCID 224929241-Methoxy-1,1'-bicyclohexane-4-one수율 107.1%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 8-cyclohexyl-8-methoxy-1,4-dioxaspiro[4.5]decane (1.15 g) and acetic acid (40 ml) in water was stirred at 100° C. for 6 hours. After cooling to room temperature, the reaction mixture was added to a mixture of sodium hydrogen carbonate solution and diethyl ether. The organic layer was taken, washed with sodium hydrogen carbonate solution and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was concentrated under reduced pressure to give 1-methoxy-1,1′-bicyclohexane-4-one (1.018 g).

후처리

  1. washwashed with sodium hydrogen carbonate solution
  2. dry with materialdried over magnesium sulfate
  3. filtrationThe magnesium sulfate was filtered off
  4. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-b6fc3e30c9844efebb1d782acaae039c
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06884868B1

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