Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → 2-chloro-7-(2-fluorobenzyl)-4-(2-furyl)-7H-pyrrolo[2,3-d]pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | alpha-Bromo-o-fluorotoluene | HCID 67968 | — |
| 반응물 | HCID 178418860 | HCID 178418860 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-chloro-7-(2-fluorobenzyl)-4-(2-furyl)-7H-pyrrolo[2,3-d]pyrimidine | HCID 21976427 | 76.3% |
반응 단계
A solution of 2-chloro4(2-furyl)-1H-pyrrolo[2,3-d]pyrimidine (219 mg, 1 mmol) in DMF (2 mL) at 0° C. was treated with NaH (40 mg, 60%, 1 inmol), stirred for 20 min, treated with 2-fluorobenzyl bromide (120 μL, 1 mmol), stirred at room temperature for 1 h, quenched with water, extracted with EtOAc, dried (MgSO4), concentrated in vacuo and purified by chromatography (EtOAc:Heptane, 1:4) to give the title compound (250 mg, 76%) as a cream solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07598256B2 |
| 출처 데이터셋 | uspto-grants-2009_10 |
| ORD ID | ord-4035ab3283754a3fbfd54936822a479b |
| 출처 메모 | uspto-grants-2009_10 |