Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1817177생성일: 2026년 10월 26일
Veratrylamine → N-(3,4-dimethoxybenzyl)-7-(2-fluorobenzyl)4-(2-furyl)-7H-pyrrolo[2,3-d]pyrimidine-2-amine
https://huagongshe.com/reaction/1817177
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Veratrylamine | HCID 79832 | — |
| 반응물 | 2-chloro-7-(2-fluorobenzyl)-4-(2-furyl)-7H-pyrrolo[2,3-d]pyrimidine | HCID 21976427 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | N-(3,4-dimethoxybenzyl)-7-(2-fluorobenzyl)4-(2-furyl)-7H-pyrrolo[2,3-d]pyrimidine-2-amine | HCID 21976416 | 88.4% |
반응 단계
A solution of 2-chloro-7-(2-fluorobenzyl)-4-(2-furyl)-7H-pyrrolo[2,3-d]pyrimidine (254 mg, 0.78 mmol) in N-methylpyrrolidone (2 mL) was treated with veratrylamine (0.25 mL, 1.66 mmol), heated to 100° C. for 16 h and purified by chromatography (Heptane:EtOAc, 4:1) to give the title compound (316 mg, 88%) as a cream solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07598256B2 |
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| 출처 데이터셋 | uspto-grants-2009_10 |
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| ORD ID | ord-1c36fde3337d4a65b799365dc4a52858 |
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| 출처 메모 | uspto-grants-2009_10 |
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