Piperidine → 7,7-Dimethyl-5-oxo-2-piperidin-1-yl-5,6,7,8-tetrahydro-quinoline-3-carbonitrile

HRID 1817816노트

반응식

HRID 1817816 반응식
[CH3:1][C:2]1([CH3:17])[CH2:11][C:10]2[N:9]=[C:8](SC)[C:7]([C:14]#[N:15])=[CH:6][C:5]=2[C:4](=[O:16])[CH2:3]1.[NH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1>C(O)C>[CH3:1][C:2]1([CH3:17])[CH2:11][C:10]2[N:9]=[C:8]([N:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[C:7]([C:14]#[N:15])=[CH:6][C:5]=2[C:4](=[O:16])[CH2:3]1

참가 물질

4

반응물 2

HCID 8082PiperidineHCID 31375507,7-Dimethyl-2-methylsulfanyl-5-oxo-5,6,7,8-tetrahydro-quinoline-3-carbonitrile

생성물 1

HCID 578831717,7-Dimethyl-5-oxo-2-piperidin-1-yl-5,6,7,8-tetrahydro-quinoline-3-carbonitrile수율 28.2%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 7,7-dimethyl-2-methylsulfanyl-5-oxo-5,6,7,8-tetrahydro-quinoline-3-carbonitrile (0.25 g, 1 mmol) and piperidine (0.32 ml, 4 mmol) in dry ethanol (3 ml) was stirred at reflux for 36 h. The reaction mixture was then evaporated under reduced pressure. The residue was purified by flash chromatography on silica gel (chloroform-methanol, 50:1) to give the title compound (0.08 g, 28%) as a colorless solid.

후처리

  1. temperatureat reflux for 36 h
  2. customThe reaction mixture was then evaporated under reduced pressure
  3. customThe residue was purified by flash chromatography on silica gel (chloroform-methanol, 50:1)

출처 및 근거

ORD 기록
ord-61ad601957ff441aa8913a521fedbe52
출처 데이터셋
uspto-grants-2009_10
특허 번호
US07598384B2

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