Trimethyl((2-nitrophenyl)ethynyl)silane → HCID 57883359, 화합물
반응식
[CH3:1][Si:2]([CH3:15])([CH3:14])[C:3]#[C:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N+:11]([O-])=O>CO.[Pd]>[CH3:14][Si:2]([CH3:1])([CH3:15])[CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[NH2:11]참가 물질
4
실험 절차
10.9 g (50 mmol) of trimethyl-(2-nitrophenylethynyl)silane were dissolved in 200 ml of methanol, and 0.5 g of palladium-on-carbon (5%) were added. The mixture was then hydrogenated in an autoclave at 4 bar for 12 h. Removal of the solvent and column-chromatographic purification on silica gel 60 (mobile phase: methylene chloride) gave 4.1 g of 2-(2-trimethylsilylethyl)phenylamine [log P (pH 2.3)=2.58].
후처리
- customRemoval of the solvent and column-chromatographic purification on silica gel 60 (mobile phase: methylene chloride)
출처 및 근거
- ORD 기록
- ord-d1119feb7f484e87805b6e04cb9b5057
- 출처 데이터셋
- uspto-grants-2009_10
- 특허 번호
- US07598389B2
반응 노트
불러오는 중…