Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperidine → (E,E)-2-(3-Fluorobenzylaminocarbonyl)-3-(3,4-dihydroxystyryl)acrylonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 3-(3,4-Dihydroxy-phenyl)-2-propenal | HCID 443034 | — |
| 반응물 | 2-cyano-N-[(3-fluorophenyl)methyl]acetamide | HCID 28970880 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | (E,E)-2-(3-Fluorobenzylaminocarbonyl)-3-(3,4-dihydroxystyryl)acrylonitrile | HCID 11500983 | — |
반응 단계
The compound was prepared as described in Example 37 by adding piperidine to a solution of 3,4-dihydroxycinnamaldehyde (35 mg, 0.2 mmol) and 2-cyano-N-(3-fluorobenzyl)acetamide (38 mg, 0.2 mmol) in ethanol. After recrystallization from ethanol-water a yellow solid was obtained (51 mg, 75%). The product gave the following analytical data:
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07598419B2 |
| 출처 데이터셋 | uspto-grants-2009_10 |
| ORD ID | ord-8b4890e42bc4430b84d5f68d83900e42 |
| 출처 메모 | uspto-grants-2009_10 |