1-(3-Aminopropyl)-2-pyrrolidinone → 1-[3-(3-Nitro-7-phenylquinolin-4-ylamino)propyl]pyrrolidin-2-one

HRID 1818160

반응식

HRID 1818160 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[N+:18]([O-:20])=[O:19].[NH2:21][CH2:22][CH2:23][CH2:24][N:25]1[CH2:29][CH2:28][CH2:27][C:26]1=[O:30]>>[N+:18]([C:3]1[CH:4]=[N:5][C:6]2[C:11]([C:2]=1[NH:21][CH2:22][CH2:23][CH2:24][N:25]1[CH2:29][CH2:28][CH2:27][C:26]1=[O:30])=[CH:10][CH:9]=[C:8]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH:7]=2)([O-:20])=[O:19]

참가 물질

3

반응물 2

HCID 821111-(3-Aminopropyl)-2-pyrrolidinoneHCID 219843354-Chloro-3-nitro-7-phenylquinoline

생성물 1

HCID 219840791-[3-(3-Nitro-7-phenylquinolin-4-ylamino)propyl]pyrrolidin-2-one수율 88.1%

실험 절차

4-Chloro-3-nitro-7-phenylquinoline (3.51 g, 12.3 mmol) was treated with 1-(3-aminopropyl)pyrrolidin-2-one (2.3 mL, 16 mmol) according to the method described in Part E of Example 1 to provide 4.23 g of 1-[3-(3-nitro-7-phenylquinolin-4-ylamino)propyl]pyrrolidin-2-one as a yellow solid.

출처 및 근거

ORD 기록
ord-7e5aa140798847a2b105e14299930dad
출처 데이터셋
uspto-grants-2009_10
특허 번호
US07598382B2

연결된 노트

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