5-Aminothiazole 2-mercaptopropionic acid ethyl ester → HCID 178461381, 화합물
반응식
C(OC(=O)C([S:7][C:8]1[S:12][C:11]([NH:13][C:14]([N:16]([CH:24]2[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)[C@H:17]2[CH2:22][CH2:21][C@H:20]([CH3:23])[CH2:19][CH2:18]2)=[O:15])=[N:10][CH:9]=1)C)C.C1(N[C@H]2CC[C@H](C)CC2)CCCCCC1.NC1SC=NC=1.C([O:55][C:56](=[O:60])[CH:57](S)[CH3:58])C>>[CH:24]1([N:16]([C@H:17]2[CH2:18][CH2:19][C@H:20]([CH3:23])[CH2:21][CH2:22]2)[C:14](=[O:15])[NH:13][C:11]2[S:12][C:8]([S:7][CH2:58][CH2:57][C:56]([OH:60])=[O:55])=[CH:9][N:10]=2)[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]1참가 물질
4
실험 절차
{2-[3-Cycloheptyl-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-propionic acid ethyl ester prepared as described in general procedure (A) using cycloheptyl-(trans-4-methylcyclohexyl)-amine and 5-aminothiazole-2-mercaptopropionic acid ethyl ester. Hydrolysis using general procedure (F) gave the title compound.
후처리
- customHydrolysis