Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylcarbamoyl Chloride → HCID 178484667, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylcarbamoyl Chloride | HCID 6598 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | HCID 178461370 | HCID 178461370 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | HCID 178484667 | HCID 178484667 | — |
반응 단계
To a solution of 3-(5-chloro-thiazol-2-yl)-1-(trans-4-methyl-cyclohexyl)-1-piperidin-4-yl-urea (0.8 mmol), prepared as described in general procedure (G), steps 1-3, and 1.2 equivalents of DIPEA in 10 mL dioxane was added dimethylcarbamoyl chloride (1.2 equivalents) in 1 ml dioxane. The reaction was stirred overnight at room temperature, concentrated in vacuo and purified by flash chromatography to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07598391B2 |
| 출처 데이터셋 | uspto-grants-2009_10 |
| ORD ID | ord-56f39b750561483cbd5c2e8695559dd6 |
| 출처 메모 | uspto-grants-2009_10 |