Methyl 4-hydroxy-2,5-dimethylbenzoate → HCID 66781990, 화합물

반응식

[NH2:1][C:2]1[CH:3]=[C:4]([C:9]([CH3:15])([CH3:14])[C:10]([O:12]C)=[O:11])[CH:5]=[CH:6][C:7]=1[CH3:8].[CH3:16][C:17]1[CH:25]=[C:24]([O:26][CH2:27][C@@H:28]2[CH2:33][N:32]([CH3:34])[C:31]3[CH:35]=[CH:36][CH:37]=[CH:38][C:30]=3[O:29]2)[C:23]([CH3:39])=[CH:22][C:18]=1[C:19](Cl)=[O:20].OC1C(C)=CC(C(OC)=O)=C(C)C=1>>[CH3:16][C:17]1[CH:25]=[C:24]([O:26][CH2:27][C@@H:28]2[CH2:33][N:32]([CH3:34])[C:31]3[CH:35]=[CH:36][CH:37]=[CH:38][C:30]=3[O:29]2)[C:23]([CH3:39])=[CH:22][C:18]=1[C:19]([NH:1][C:2]1[CH:3]=[C:4]([C:9]([CH3:15])([CH3:14])[C:10]([OH:12])=[O:11])[CH:5]=[CH:6][C:7]=1[CH3:8])=[O:20]

참가 물질

반응물 3

HCID 22615980Methyl 4-hydroxy-2,5-dimethylbenzoate

HCID 23125474HCID 23125474, 화합물

HCID 86609831HCID 86609831, 화합물

생성물 1

HCID 66781990HCID 66781990, 화합물수율 66.2%

실험 절차

By the same procedures as a series of Example 18 and Example 19 using methyl 2-(3-amino-4-methylphenyl)-2-methylpropanoate (132 mg)(the compound prepared by the same procedures as Example 16) and 2,5-dimethyl-4-(((2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzoylchloride (210 mg)(the compound prepared by the same procedures as a series of Example 8→Example 9→Example 10 using methyl 4-hydroxy-2,5-dimethylbenzoate.), the title compound (202 mg) having the following physical data was obtained.