7-iodo-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-one → 1-[1-(2-Chloro-3,6-difluorophenyl)ethyl]-7-iodo-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-one

HRID 1819079노트

반응식

HRID 1819079 반응식
[I:1][C:2]1[CH:12]=[N:11][C:5]2[NH:6][CH2:7][C:8](=[O:10])[NH:9][C:4]=2[CH:3]=1.Br[CH:14]([C:16]1[C:21]([Cl:22])=[C:20]([F:23])[CH:19]=[CH:18][C:17]=1[F:24])[CH3:15]>>[Cl:22][C:21]1[C:20]([F:23])=[CH:19][CH:18]=[C:17]([F:24])[C:16]=1[CH:14]([N:9]1[C:8](=[O:10])[CH2:7][NH:6][C:5]2[N:11]=[CH:12][C:2]([I:1])=[CH:3][C:4]1=2)[CH3:15]

참가 물질

3

반응물 2

HCID 448291147-iodo-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-oneHCID 578860042-(1-Bromoethyl)-3-chloro-1,4-difluorobenzene

생성물 1

HCID 583278021-[1-(2-Chloro-3,6-difluorophenyl)ethyl]-7-iodo-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-one수율 11%

실험 절차

7-Iodo-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-one (2.935 g) was treated with 2-(1-bromoethyl)-3-chloro-1,4-difluorobenzene (Preparation 3) as in General Procedure 1 to give the title compound as an orange solid (11% yield). LCMS: m/z=449.86 (M+H+), 1H-NMR (DMSO-d6, 400 MHz) δ 1.79 (3H, m), 2.73 (1H, s), 2.89 (1H, s), 5.76 (1H, m), 6.96 (1H, s), 7.29 (1H, m), 7.43 (1H, m), 7.62 (1H, s), 7.83 (1H, m).

출처 및 근거

ORD 기록
ord-29749fe809d04466ac187dbd7d1cc7d3
출처 데이터셋
uspto-grants-2009_10
특허 번호
US07601716B2

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