Dimethylformamide → 6-chloropyrazine-2-carboxamide
반응식
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([Cl:8])[N:3]=1.[C-]#N.[K+].C[N:13]([CH:15]=[O:16])C>O>[Cl:8][C:4]1[N:3]=[C:2]([C:15]([NH2:13])=[O:16])[CH:7]=[N:6][CH:5]=1참가 물질
5
반응 조건
- 온도
- 100 °C
실험 절차
To a solution of 2,6-dichloropyrazine (50 mg, 0.34 mmol) in DMF (1 mL) was added a solution of potassium cyanide (24 mg, 0.37 mmol) in H2O (1 mL). After stirring for 3 h at 100° C., the reaction mixture was cooled to r.t., poured into H2O (10 mL) and extracted with EtOAc three times. The combined organic layer was dried over MgSO4, filtered and concentrated. The crude product was purified by column chromatography (silica gel, EtOAc:Hexane, 3:7) to give 15 mg of the desired product. Yield: 32%.
후처리
- temperaturethe reaction mixture was cooled to r.t.
- extractionextracted with EtOAc three times
- dry with materialThe combined organic layer was dried over MgSO4
- filtrationfiltered
- concentrationconcentrated
- customThe crude product was purified by column chromatography (silica gel, EtOAc:Hexane, 3:7)
출처 및 근거
- ORD 기록
- ord-9e0f0398cae6462da726ec20f7bfbc89
- 출처 데이터셋
- uspto-grants-2009_10
- 특허 번호
- US07601742B2
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