1-Butanaminium, N,N,N-tributyl-, fluoride, hydrate → 1-[5-fluoro-3-(3-fluoro-benzyl)-7-(1H-pyrrol-3-yl)-benzofuran-2-yl]-ethanone

HRID 18195

반응식

HRID 18195 반응식
[F:1][C:2]1[CH:3]=[C:4]([C:22]2[CH:26]=[CH:25][N:24]([Si](C(C)C)(C(C)C)C(C)C)[CH:23]=2)[C:5]2[O:9][C:8]([C:10](=[O:12])[CH3:11])=[C:7]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[CH:15]=3)[C:6]=2[CH:21]=1.O.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1>[F:1][C:2]1[CH:3]=[C:4]([C:22]2[CH:26]=[CH:25][NH:24][CH:23]=2)[C:5]2[O:9][C:8]([C:10](=[O:12])[CH3:11])=[C:7]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[CH:15]=3)[C:6]=2[CH:21]=1

참가 물질

4

반응물 2

HCID 162116731-Butanaminium, N,N,N-tributyl-, fluoride, hydrateHCID 593449101-[5-fluoro-3-(3-fluoro-benzyl)-7-(1-triisopropylsilanyl-1H-pyrrol-3-yl)-benzofuran-2-yl]-ethanone

생성물 1

HCID 593448981-[5-fluoro-3-(3-fluoro-benzyl)-7-(1H-pyrrol-3-yl)-benzofuran-2-yl]-ethanone수율 79%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

1-[5-Fluoro-3-(3-fluoro-benzyl)-7-(1-triisopropylsilanyl-1H-pyrrol-3-yl)-benzofuran-2-yl]-ethanone (0.38 gm, 0.748 mmol) and tetrabutylammonium fluoride hydrate (0.28 gm, 0.89 mmol) were added to tetrahydrofuran (10 ml) and stirred at room temperature for four hours. The solution was concentrated under reduced pressure and purified by column chromatography to give 1-[5-fluoro-3-(3-fluoro-benzyl)-7-(1H-pyrrol-3-yl)-benzofuran-2-yl]-ethanone (0.205 gm, 79% yield).

후처리

  1. concentrationThe solution was concentrated under reduced pressure
  2. custompurified by column chromatography

출처 및 근거

ORD 기록
ord-ea46eb9885f64499b73736a5e2e99557
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741326B2

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