2-Amino-4,5,6,7-tetrahydrobenzothiazole → HCID 11618584, 화합물

HRID 1819735노트

반응식

HRID 1819735 반응식
[CH2:1]1[CH2:5][N:4]([C:6]2[CH:11]=[CH:10][C:9]([C:12]([CH2:14][Br:15])=[O:13])=[CH:8][CH:7]=2)[CH2:3][CH2:2]1.[NH2:16][C:17]1[S:18][C:19]2[CH2:25][CH2:24][CH2:23][CH2:22][C:20]=2[N:21]=1>>[BrH:15].[NH:16]=[C:17]1[N:21]([CH2:14][C:12]([C:9]2[CH:10]=[CH:11][C:6]([N:4]3[CH2:5][CH2:1][CH2:2][CH2:3]3)=[CH:7][CH:8]=2)=[O:13])[C:20]2[CH:22]=[CH:23][CH:24]=[CH:25][C:19]=2[S:18]1

참가 물질

3

반응물 2

HCID 180462-Amino-4,5,6,7-tetrahydrobenzothiazoleHCID 36817854-(Pyrrolidin-1-yl)phenacyl bromide

생성물 1

HCID 11618584HCID 11618584, 화합물수율 43%

실험 절차

The title compound is prepared from α-bromo-4-(1-pyrrolidino)acetophenone and 2-amino-4,5,6,7-tetrahydrobenzothiazole using method A in 43% yield: mp 285-290° C. (dec); 1H-NMR (DMSO-d6) 2.00 (s, 4H), 3.38 (m, 4H), 5.93 (s, 2H), 6.68 (d, 2H), 7.43 (t, 1H), 7.50 (t, 1H), 7.57 (d, 1H), 7.90 (d, 2H), 8.03 (d, 1H); Anal. C19H20BrN3OS (C, H, N).

출처 및 근거

ORD 기록
ord-bac7552edd8845239e9bd2b97e89cff7
출처 데이터셋
uspto-grants-2009_10
특허 번호
US07601846B2

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