Cyclopropanecarboxylic acid → HCID 10256103, 화합물

반응식

[CH3:1][C:2]([CH3:30])([CH3:29])[C:3](=[O:28])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([C:17]2[S:21][C:20]([S:22]([NH2:25])(=[O:24])=[O:23])=[C:19]([CH3:26])[CH:18]=2)([CH2:15][CH3:16])[CH2:13][CH3:14])=[CH:8][C:7]=1[CH3:27].[CH:31]1([C:34](O)=[O:35])[CH2:33][CH2:32]1>>[CH:31]1([C:34]([NH:25][S:22]([C:20]2[S:21][C:17]([C:12]([C:9]3[CH:10]=[CH:11][C:6]([O:5][CH2:4][C:3](=[O:28])[C:2]([CH3:1])([CH3:29])[CH3:30])=[C:7]([CH3:27])[CH:8]=3)([CH2:13][CH3:14])[CH2:15][CH3:16])=[CH:18][C:19]=2[CH3:26])(=[O:24])=[O:23])=[O:35])[CH2:33][CH2:32]1

참가 물질

반응물 2

HCID 15655Cyclopropanecarboxylic acid

HCID 57890063HCID 57890063, 화합물

생성물 1

HCID 10256103HCID 10256103, 화합물수율 60%

실험 절차

Using a procedure analogous to Example 163, 5-{1-[4-(3,3-dimethyl-2-oxo-butoxy)-3-methyl-phenyl]-1-ethyl-propyl}-3-methyl-thiophene-2-sulfonic acid amide and cyclopropanecarboxylic acid give the title compound (60%).

출처 및 근거

ORD 기록: ord-722c35c1cd55441488580c0dbb8ee5e1
출처 데이터셋: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07601850B2

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