Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chloroform → Phenacyl bromide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chloroform | HCID 6212 | — |
| 반응물 | Acetophenone | HCID 7410 | — |
| 반응물 | Bromine | HCID 24408 | — |
| 촉매 | Acetic Acid | HCID 176 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Phenacyl bromide | HCID 6259 | — |
반응 단계
The appropriate acetophenone (Intermediate A) was dissolved in diethyl ether, methylene chloride, or chloroform, and cooled to 0° C. Bromine (1.1 equiv) was dissolved in either methylenechloride or diethyl ether and added to the solution of acetophenone via a dropping funnel. After the addition of bromine was complete 2 drops of acetic acid were added and the solution was warmed to room temperature. Solvent was removed under reduced pressure to provide crude 2-bromoacetophenone (Intermediate B) which was generally used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07741349B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-0ad0056e4b8948658799532f1f4e42e6 |
| 출처 메모 | uspto-grants-2010_06 |