Bromine → 5-Bromo-3-fluoro-2-hydroxybenzoic acid

HRID 1820107노트

반응식

HRID 1820107 반응식
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:4]([C:5]([OH:7])=[O:6])[C:3]=1[OH:11].[Br:12]Br>C(O)(=O)C.O>[Br:12][C:9]1[CH:10]=[C:2]([F:1])[C:3]([OH:11])=[C:4]([CH:8]=1)[C:5]([OH:7])=[O:6]

참가 물질

5

반응물 2

HCID 24408BromineHCID 2687243-Fluoro-2-hydroxybenzoic acid

생성물 1

HCID 117704165-Bromo-3-fluoro-2-hydroxybenzoic acid

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 962Water용매

실험 절차

5.00 g (32 mmol) of 3-fluorosalicylic acid was suspended in 50 ml of glacial acetic acid. 2.2 ml of bromine were added and the mixture was stirred at ambient temperature for 48 h. The resulting suspension was diluted with 500 ml of water and the precipitate filtered off and dried by suction to afford 9.394 g of 5-bromo-3-fluoro-2-hydroxybenzoic acid as an ivory solid.

후처리

  1. filtrationthe precipitate filtered off
  2. customdried by suction

출처 및 근거

ORD 기록
ord-fd0a2b3d96e24367b50df51d1714bec7
출처 데이터셋
uspto-grants-2009_10
특허 번호
US07601839B2

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