참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | N-(2,6-dimethyl-4-nitrophenyl)acetamide | HCID 50851089 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2,6-Dimethyl-4-nitroaniline | HCID 28159 | 97.5% |
반응 단계
Concentrated hydrochloric acid (17.5 mL) was added to N-(2,6-dimethyl-4-nitro-phenyl)-acetamide (5.05 g) and heated to 140° C. for 30 minutes in a sealed microwave process vial. The reaction mixture was neutralized with solid sodium carbonate in water and the precipitated product was collected by filtration and washed with water (100 mL) to furnish 3.93 g (97% yield) of the title compound as a yellow solid. 1H NMR (500 MHz, DMSO-d6): 2.15 (s, 6H), 6.15 (b, 2H), 7.79 (s, 2H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07601870B2 |
|---|
| 출처 데이터셋 | uspto-grants-2009_10 |
|---|
| ORD ID | ord-6495e0fce7c44ab6b87b955008f683f2 |
|---|
| 출처 메모 | uspto-grants-2009_10 |
|---|
