Water → Guanine

HRID 1820617노트

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HRID 1820617 반응식
[CH:1]1[NH:2][C:3]2[N:9]=[C:8]([NH2:10])[N:7]=[C:6](Cl)[C:4]=2[N:5]=1.C(N(CC)CC)C.C[O:20]C1C=C(C)C(S)=CC=1.O>CO>[NH:7]1[C:6](=[O:20])[C:4]2[NH:5][CH:1]=[N:2][C:3]=2[N:9]=[C:8]1[NH2:10]

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 27595964-Methoxy-2-methylbenzenethiolHCID 1785084356-chloro-1H-purin-2-amine

생성물 1

HCID 135398634Guanine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

6-Chloroguanine derivative prepared in Preparation 6 (4.86 g) was dissolved in 85 Ml of methanol and 1.4 g of triethylamine and 2.9 g of 4-methoxythiocresol were added. The reaction mixture was reacted under reflux condition for 24 hours. The reaction was stopped by adding 20 ml of water, and the methanol was removed by distillation under reduced pressure. The reaction mixture was extracted with dichloromethane and purified by silica gel column to give a compound wherein 6-position of guanine was substituted by 4-methoxyphenylthio group.

후처리

  1. additionwere added
  2. customThe reaction mixture was reacted
  3. temperatureunder reflux condition for 24 hours
  4. customthe methanol was removed by distillation under reduced pressure
  5. extractionThe reaction mixture was extracted with dichloromethane
  6. custompurified by silica gel column

출처 및 근거

ORD 기록
ord-73eaabc63dc848c5bb674f2004129df8
출처 데이터셋
uspto-grants-2009_10
특허 번호
US07605147B2

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