tert-Butyl piperazine-1-carboxylate → 4-(4-Oxazol-2-yl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

반응식

Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][CH:10]=[CH:11][N:12]=2)=[CH:4][CH:3]=1.[C:13]([N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1)([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14]>>[C:16]([O:15][C:13]([N:20]1[CH2:25][CH2:24][N:23]([C:2]2[CH:7]=[CH:6][C:5]([C:8]3[O:9][CH:10]=[CH:11][N:12]=3)=[CH:4][CH:3]=2)[CH2:22][CH2:21]1)=[O:14])([CH3:19])([CH3:17])[CH3:18]

참가 물질

반응물 2

HCID 143452tert-Butyl piperazine-1-carboxylate

HCID 110750322-(4-Bromophenyl)oxazole

생성물 1

HCID 690421064-(4-Oxazol-2-yl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

실험 절차

Prepared in analogy to example 4.4(a) from 2-(4-Bromo-phenyl)-oxazole and N-BOC-piperazine. MS (m/e): 330.3 (MH+, 100%)

출처 및 근거

ORD 기록: ord-275017efc1a649c28075ce72b02ca2c8
출처 데이터셋: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07605163B2

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