2,6-Difluorobenzoic acid → 3-(Chlorosulfonyl)-2,6-difluorobenzoic acid

반응식

[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([OH:6])=[O:5].[Cl:12][S:13](O)(=[O:15])=[O:14]>>[Cl:12][S:13]([C:8]1[C:7]([F:11])=[C:3]([C:2]([F:1])=[CH:10][CH:9]=1)[C:4]([OH:6])=[O:5])(=[O:15])=[O:14]

참가 물질

반응물 2

HCID 97962,6-Difluorobenzoic acid

HCID 24638Chlorosulfonic acid

생성물 1

HCID 33047963-(Chlorosulfonyl)-2,6-difluorobenzoic acid

반응 조건

온도: 150 °C

실험 절차

77 mmol of 2,6-difluorobenzoic acid were dissolved in 15.5 ml of chlorosulfonic acid and stirred for 2 h at 150° C. The reaction mixture was cooled to room temperature and poured into 100 ml of ice/water. The solid was filtered and dried to yield the title compound as a colorless solid. MS (m/e): 255.1 (M−H, 44%)

후처리

temperatureThe reaction mixture was cooled to room temperature
filtrationThe solid was filtered
customdried

출처 및 근거

ORD 기록: ord-be62131d80f34be195f70e78d8d01ef0
출처 데이터셋: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07605163B2

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